The publisher's final edited version of this article is available at Receptors Clin Investig See other articles in PMC that cite the published article. Abstract Pulmonary hypertension complicating idiopathic pulmonary fibrosis, also known as secondary pulmonary hypertension, represents a major source of morbidity and mortality in affected patients. While the study of primary pulmonary arterial hypertension has yielded several therapies, the same is not true for the treatment of pulmonary hypertension secondary to pulmonary fibrosis. Recent studies have indicated an important role of hypoxia-inducible factor HIF — a regulatory protein that is vital in adaptation to hypoxic conditions — in the development of secondary pulmonary hypertension.
Benjamin Franklin, The Way to Wealth I endeavoured to make it both entertaining and useful, and it accordingly came to be in such demand, that I reaped considerable profit from it, vending annually near ten thousand.
And observing that it was generally read, scarce any neigbbourbood in the province being without it, I considered it as a proper vehicle for conveying instruction among the common people, who bought Scarcely any other books.
I therefore filled all the little spaces, that occurred between the remarkable days in the Calendar, with proverbial sentences, chiefly such as inculcated industry and frugality, as the means of procuring wealth, and thereby securing virtue; it being more difficult for a man in want to act always honestly, as to use here one of those proverbs It is hard for an empty sack to stand upright" Courteous Reader, I have heard, that nothing gives an author so great pleasure as to find his works respectfully quoted by others.
Judge, then, how much I must have been gratified by an incident I am going to relate, to you. Istopped my horse lately, where a great number of people were collected at an auction of merchants' goods.
The hour of the sale not being come, they were conversing on the badness of the times; and one of the company called to a plain, clean, old man, with white locks, "Pray, Father Abraham, what think you of the times?
Will not these heavy taxes quite ruin the country? How shall we ever be able to pay them? What would you advise us to? We are taxed twice as much by our idleness, three times as much by our pride, and four times as much by our folly; and from these taxes the commissioners cannot ease or deliver us, by allowing an abatement.
However, let us hearken to good advice, and something may be done for us; God helps them that help themselves, as Poor Richard says. It would be thought a hard government, that should tax its people one-tenth part of their time, to be employed in its service; but idleness taxes many of us much more; sloth, by bringing on diseases, absolutely shortens life.
Sloth, like rust, consumes faster than labor wears; while the used key is always bright, as Poor Richard says. But dost thou love life, then do not squander time, for that is the stuff life is made of, as Poor Richard says.
How much more than is necessary do we spend in sleep, forgetting, that The sleeping fox catches no poultry, and that There will be sleeping enough in the grave, as Poor Richard says. Let us then up and be doing, and doing to the purpose; so by diligence shall we do more with less perplexity.
Sloth makes all things difficult, but industry all easy; and He that riseth late must trot all day, and shall scarce overtake his business at night; while Laziness travels so slowly, that Poverty soon overtakes him. Drive thy business, let not that drive thee; and Early to bed, and early to rise, makes a man healthy, wealthy, and wise, as Poor Richard says.
We may make these times better, if we bestir ourselves. Industry need not wish, and he that lives upon hopes will die fasting.
There are no gains without pains; then help, hands, for I have no lands; or, if I have, they are smartly taxed. He that hath a trade hath an estate; and he that hath a calling, hath an office of profit and honor, as Poor Richard says; but then the trade must be worked at, and the calling followed, or neither the estate nor the office will enable us to pay our taxes.
If we are industrious, we shall never starve; for, At the working man's house hunger looks in, but dares not enter. Nor will the bailiff or the constable enter, for Industry pays debts, while despair increaseth them.
What though you have found no treasure, nor has any rich relation left you a legacy, Diligence is the mother of good luck, and God gives all things to industry. Then plough deep while sluggards sleep, and you shall have corn to sell and to keep.
Work while it is called to-day, for you know not how much you may be hindered to-morrow. One, to-day is worth two to-morrows, as Poor Richard says; and further, Never leave that till to-morrow, which you can do to-day.
If you were a servant, would you not be, ashamed that a good master should catch you idle? Are you then your own master? Be ashamed to catch yourself idle, when there is so much to be done for yourself, your family, your country, and your king. Handle your tools without mittens; remember, that The cat in gloves catches no mice, as Poor Richard says.
It is true there is much to be done, and perhaps you are weak-handed; but stick to it steadily, and you will see great effects; for Constant dropping wears away stones; and By diligence and patience the mouse ate in two the cable; and Little strokes fell great oaks.
Leisure is time for doing something useful; this leisure the diligent man will obtain, but the lazy man never; for A life of leisure and a life of laziness are two things.
Many, without labor, would live by their wits only, but they break for want of stock; whereas industry gives comfort, and plenty, and respect. Fly pleasures, and they will follow you. The diligent spinner has a large shift; and now I have a sheep and a cow, everybody bids me good morrow.
But with our industry we must likewise be steady, settled, and careful, and oversee our own affairs with our own eyes, and not trust too much to others. Trusting too much to others' care is the ruin of many; for In the affairs of this world men are saved, not by faith, but by the want of it.
So much for industry, my friends, and attention to one's own business; but to these we must add frugality if we would make our industry more certainly successful.Beware of little expenses.
A small leak will sink a great ship meaning. It is the small costs that will cause you to go over your budget, drain any savings that you have, and leave your finances in disarray. Beware, Expenses, Great, Leak, Little, Ship, Sink, Small, Will Quotes to Explore There are two great days in a person's life - the day we are born and the day we discover why.
Which of these experiences best illustrates the meaning of Franklin's aphorism "A small leak will sink a great ship" A small rip tears more and more, eventually destroying your favorite pair of pants Which of these experiences best illustrates the meaning of Franklin's aphorism "Keep thy .
Benjamin Franklin said, “Beware of little expenses; a small leak will sink a great ship.” Does this describe your finances?
More often than not, budgets are wrecked or debt is accumulated by little things. Sure, those big surprise expenses also strain our finances, but we can probably credit smaller, sneaky expenses for doing the real damage.
Beware of little; a small leak will sink a great ship. Franklin. Read also: Essay on Population Explosion in the World with outlines. As there is no simple cause of this huge problem, there is no simple cure. The best remedy is to curb consumption positively, from the habit of saving both at private and public levels and increase local and.
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In an essay, extend this comparison by using details from his autobiography. In Poor Richard’s Almanack, compare these two aphorisms: “A small leak will sink a great ship,” and “For want of a nail, the shoe is lost; for want of a shoe, the horse is lost; for want of a horse, the rider is lost.”.