The use of regenerative medicine in revolutionizing organ transplantation

Stem cell therapy's concept is deceptively simple: However, the reality falls far short of the dream. When will the promises of revolutionizing medical treatment become reality?

The use of regenerative medicine in revolutionizing organ transplantation

Regenerative Medicine The Future of Plastic Surgery Regenerative medicine is the science of using adipose-derived stem cells harvested from fat to regenerate cells and tissues in the human body. Patient Safety What is regenerative medicine?

Regenerative medicine is the science of replacing, engineering or regenerating human cells, tissues or organs to restore or establish normal form and function.

Applications of regenerative medicine in organ transplantation

This broadly encompasses the use of cells, tissues, drugs, synthetic biomaterials and devices to help patients heal more effectively from trauma, cancer therapy, other disease processes and birth anomalies. Regenerative medicine therapies can have goals of both healing damaged tissues and forming new tissue.

While many clinicians and scientists across all fields of medicine have been involved in regenerative medicine research and clinical advances over the last two decades, plastic surgeons have been especially instrumental in moving new therapies into the clinical arena and having a leadership role in new scientific discoveries.

Areas of ongoing research and clinical care: Plastic surgeons have been pioneers in the use of protein scaffolds to generate the dermal layer, or innermost layer of the skin, following burn injury. Plastic surgeons, in the practice of hand and upper extremity surgery, as well as lower extremity surgery, are forging new paths in the science of regenerating nerves and restoring optimal function after nerve injury.

These therapies involve the use of special growth factors to stimulate nerve healing, as well as special biomaterials to serve as guides to direct the growth of nerve fibers. Breast reconstruction is a vital part of cancer therapy for many women.

Plastic surgeons are achieving better outcomes through the use of decellularized tissue scaffolds to regenerate new tissue layers over implants in breast cancer survivors. Complex wounds that are difficult to heal represent a major focus for tissue engineering and regenerative medicine strategies.

Skin substitutes, composed of living cells grown in a laboratory, are used to heal these types of wounds. Additionally, growth factors are being explored for improving wound healing.

One of the most significant breakthroughs in regenerative therapy for wound healing has been the use of negative pressure devices.

Discovered by a plastic surgeon, these devices use negative pressure and micro-mechanical forces to stimulate wound healing. Fat grafting and adipose stem cell therapy: A significant advance in surgical regenerative medicine has been the development and refinement of techniques to transfer fat tissue in a minimally invasive manner.

This allows the regeneration of fat tissue in other parts of the body, using a patient's own extra fat tissue. This technique is revolutionizing many reconstructive procedures, including breast reconstruction.

Importantly, fat tissue is an important source of adult mesenchymal stem cells. Plastic surgeons are experts in the biology of scar formation and the molecular signals that impact healing.

Regenerative therapies are being developed using energy-based devices, such as laser and intense pulsed light, to improve the healing of scars. Hand and face transplantation: The ultimate in "Tissue replacement therapy," hand and face transplantation represents a life-restoring therapy for patients with severe trauma or other disease processes that result in loss of the hands or face.

The use of regenerative medicine in revolutionizing organ transplantation

Most people aren't aware of this fact, but the very first successful human organ transplant was performed by a plastic surgeon. Joseph Murray performed the first kidney transplant in Plastic surgeons have been building up on his legacy in developing this new field of hand and face transplantation.

This field also blends elements of cell therapy in order to control the immune response and reduce the need for toxic immunosuppressive drugs. Bioprosthetic interfaces — connecting humans and machine: This very interesting area of regenerative practice is directed at methods of connecting severed nerve endings with powered artificial limbs.

This often involves "rerouting" the severed nerve endings to different muscles so that sensors over the skin can detect the signals and transmit them to a computer that controls the artificial limb.

For patients suffering extensive face or a limb trauma, large segments of bone may be missing. Plastic surgeons are using calcium-based scaffolds and biomaterials derived from bone to form new bone tissue for reconstructive purposes.

In a process called "flap prefabrication," the structure is assembled using tissue grafts and then transferred to the deformity after healing.

Generation of new skin by tissue expansion: Another technique pioneered by plastic surgeons is the use of gradual expansion of implanted balloon devices to generate new skin tissue that can cover a deformity.

Regenerative Medicine | American Society of Plastic Surgeons

This technique is revolutionizing breast reconstruction and the treatment of many birth anomalies.Regenerative medicine is a broad field that includes tissue engineering but also incorporates research on self-healing – where the body uses its own systems, sometimes with help foreign biological material to recreate cells and rebuild tissues and organs.

The terms “tissue engineering” and “regenerative medicine” have become largely interchangeable, as the field hopes to focus on cures instead of treatments for .

Once we can successfully “bridge the gap,” organ transplants will become a procedure of the past and chronic diabetic wounds will be a simple fix, prompting us to step into the future of self-regenerative medicine, and allowing the human race to live longer and healthier lives.

Regenerative medicine as applied to solid organ transplantation: current status and future challenges. Giuseppe Orlando 1,2, Pedro Baptista 2, Martin Birchall 3, Paolo De Coppi 4, Alan Farney 5, The respiratory organ on which RM .

Regeneration could, in some instances, take the place of transplantation, eliminating the obstacles of getting a matching donor and being on powerful medications to prevent organ transplant rejection. For those with hypothyroidism, thyroid gland regeneration would eliminate the .

Senior study author Dr. Anthony Atala, who directs the Institute for Regenerative Medicine at Wake Forest Baptist Medical Center made his wish for this kind of tech known back in a TED talk.

Regenerative medicine is changing the premise of solid organ transplantation, requiring transplantation investigators to become familiar with regenerative medicine investigations that can be extremely relevant to their work.

Regenerative Medicine | American Society of Plastic Surgeons